Industry 4.0 is revolutionizing and revitalizing all the industrial operations. Companies are facing new challenges but also taking advantages from the multiple opportunities offered by the fourth industrial revolution. The conference provides a unique opportunity to meet scientists, researchers and company managers working in the area of Smart Manufacturing and Industry 4.0. The conference is also located with a dedicated Smart Manufacturing B2B event organised by the European Enterprise Network. This double and colocated event is, therefore, an opportunity to make networking, to create new synergies and collaborations, to develop new ideas for research and business.