Over the past few years, the growing and intensive development of information technology in the manufacturing industry has led to a significant change in the methods and tools supporting the factories of the future. The hot topics around Industry 4.0 and smart manufacturing aim at the digital and organizational transformation of traditional factories and industrial systems as well as several other sectors. The International Conference on Industry 4.0 and Smart Manufacturing (ISM) provides the perfect setting and a unique opportunity for knowledge exchange, the review and discussion of theoretical advances, research results, and industrial experiences, among scientists, researchers, decision makers, practitioners and students.