Every year, the I3M Multiconference renovates the opportunity to bring together researchers, scientists and practitioners, from the Mediterranean Area, Latin & North Americas, Europe, Asia, Africa and Australia, who are concerned with Modeling and Simulation in Industry and Academia. As a result of the joint effort of many scientific excellences, I3M is an opportunity to meet and discuss and, as usually happens, constructive debate makes people open up, brings food for thoughts as well as new ways to explore encouraging multi-disciplinary cooperation and collaborations.